It also contains a complete crossindex into the chemicals of the second half. Very little data exists about the pharmacological properties. Lets get right to it these books are about drugs and their potential positive uses. When the addition was complete, the reflux was maintained for an additional 15 min and then the. The reaction mixture was stirred for an additional 30 min, and the intermediate indoleglyoxyl chloride separated as a yellow crystalline solid but was not isolated. The residue was distilled in a kugelrohr apparatus and the solid distillate recrystallized from etoachexane to give 0. The substance was used together with its phosphoryloxyanalog ethocybin in human clinical trials in the. Its synthesis is described in his book tihkal along with reports by people who had ingested the compound.
Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at r 3 to an amino group via an ethyl side chain. The acetic acid ester of 4 ho det is known as 4 aco det or ethacetin. However, despite its structural similarity to dmt, its activity is induced by an oral dose of around 50100 mg, without the aid of mao inhibitors, and the effects last for about 2 4. The reaction mixture was stirred for an additional 30 min, and the yellow crystalline solid was removed by filtration and dissolved in 10 ml of anhydrous thf. When the addition was complete, the reaction mixture was brought to a reflux for 15 min. Shulgin reported a dosage of 20mg orally to be without effects. The phosphoric acid ester of 4hodet is known as 4 phosphoryloxy det, cey19, or ethocybin history. The acetic acid ester of 4hodet is known as 4 aco det. The phosphate ester, psilocybin, requires two additional steps. This was added dropwise at a rate that maintained the reaction at reflux. Alexander shulgin and ann shulgin which was published in 1991. To 8 ml of a stirred solution of lah 1 m in thf under n 2, there was added dropwise a solution of 0. In it he writes that he truly doubts that there is another psychedelic drug, anywhere, that can match this one for speed, for intensity, for brevity, and sensitive to dose, at least one that is active orally. The continuation is a 1997 book written by alexander shulgin and ann shulgin about a family of psychoactive drugs known as tryptamines.
Tihkal tryptamines i have known and loved is the continuation of the shulgins earlier book, pihkal phenethylamines i have known and loved. It is the 4 hydroxyl analog of dipropyltryptamine dpt. Following the publication of its synthesis by david b. The chemistry continues by alexander and ann shulgin. There was then added an excess of 2n hcl, the mixture cooled, and the resulting solids removed by filtration. A chemical love story, tihkal is an acronym that stands for tryptamines i have known and loved. The first half of tihkal is an excellent commentary on the shulgins personal experiences with tryptamines. The residue was recrystallized from etoachexane to give 0. The solid residue was recrystallized from meohet2o to give 0.
The residue was distilled at the kugelrohr and the distillate dissolved in 1 ml meoh. To 10 ml of a stirred solution of lah 1 m in thf under n 2, there was added dropwise a solution of 0. A visual index and map of tihkal, including the formatted text of book ii. It was synthesized by the noted chemist alexander shulgin and described in his book, tihkal tryptamines i have known and loved.
These were recrystallized from meoh to give, after air drying, 19. In his book tihkal, neither the minimum dosage nor the duration are reported. The subject of the work is psychoactive phenethylamine chemical derivatives, notably those that act as psychedelics andor empathogenentactogens. It is the 4 hydroxy analog of dipt and is structurally related to tryptamines like 4 ho dmt psilocin, 4 ho mipt miprocin, and 4 ho det ethocin. Tihkal is an acronym that stands for tryptamines i have known and loved. In his book tihkal tryptamines i have known and loved, the dosage is listed as 1020 mg. One equivalent of dilute hcl was added, and the volatiles were removed under vacuum.
It is found either as its crystalline hydrochloride salt or as an oily or crystalline base. After inventing lsd hoffman extracted psilocin, psilocybin, and baeocystine from psilocybe cubensis and started tweaking the psilocin molecule to see what he could come up with. It was first made by alexander shulgin and is mentioned in his book tihkal, but was never tested by him. To 8 ml of a stirred solution of lah 1 m in thf under n2, there was added dropwise a solution of 0. Det, also known under its chemical name n,ndiethyltryptamine and as t9, is a psychedelic drug closely related to dmt and 4 ho det. The main title is an acronym that stands for phenethylamines i have known and loved. Repke in 1977, its effects in humans were investigated by alexander shulgin. Shulgins trials and other anecdotal information suggest that 4homipt is a synthetic psychedelic similar in activity to psilocin.715 453 496 1474 432 866 1611 1499 730 209 1645 1479 1347 915 298 1530 1364 91 274 1197 812 1438 500 1335 494 1014 1124 889 327 824 731 1038